Thursday, November 29, 2012

Evan Longoria Baseball Contract Extension Worth $100M Through 2023

Evan Longoria pledged his loyalty to the Tampa Bay Rays by signing a multi-year baseball contract extension that could keep him in uniform through 2023, the team said on Monday.

Evan Longoria Baseball

The 27-year-old?s original deal was through 2016, but the third baseman has signed a six-year extension worth $100 million with an option for one additional year.

?In signing this contract, I kind of wanted to show that I?m committed to this organization,? Longoria told the Rays website.

?I told them from the beginning that I didn?t want to be the one sucking up all the payroll so we can?t afford anybody else, because it?s not giving us the best chance to win,? Longoria said.

?There?s no telling what the market is going to look like in five years,? added Longoria, now looking set to finish his career with the Rays. ?Obviously contracts are going up and they are probably going to continue to go up.?

Longoria was drafted by the Rays in 2006 and helped the team reach the World Series in 2008.

A three-time All Star, Longoria played in just 74 games last season because of a left hamstring ailment and also missed extended time in 2011 because of injury.

Longoria is supposed to be over his health woes and is expected to be ready for spring training.

Source: http://www.newsoxy.com/sports/evan-longoria-baseball-98842.html

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AHS, Silicon Energy turn Larson stadium 'green'

ARLINGTON ? As part of the Snohomish County PUD's voluntary "Planet Power" green energy program, AHS has installed solar panels purchased from Silicon Energy on the John C. Larson stadium.

The Arlington School District applied for a grant, available through the PUD, to fund the majority of the cost for installation, which was performed by Arlington Electric.

"Not only will this project reduce our electrical consumption, but it will also be a valuable teaching aid for our students," said Sid Logan, executive director of operations for the Arlington School District, who touted the lower impact on the environment and the cost savings of the solar panels, in addition to the educational potential of the data they will yield.

Solar photovoltaic modules, such as those manufactured by Silicon Energy in Marysville, are a viable energy source in Washington despite the state's number of rainy and cloudy days, since the temperate climate actually helps solar perform better by keeping such systems cooler.

An eight-kilowatt solar array was added to the top of the stadium, with its last four modules installed on Monday, Nov. 5. Since the solar panels produce DC power, inverters will also be installed to convert the electricity to AC.

The energy generated by this system will be used on site, at the stadium or at the school, wherever electricity is needed, to reduce the energy costs for the district and taxpayers. The solar energy will be blended with the school's regular electrical source of power, since there are times, such as at night, when solar power isn't being produced.

The project includes the creation of an interactive Internet webpage to share and monitor the system's performance with students, families and the public. The PUD's goal is to choose high profile projects so that communities can learn more about renewables and solar photovoltaics.

Source: http://feeds.soundpublishing.com/~r/northsoundbusiness/~3/P3HRyypgwdU/178068831.html

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Medicare, social program cuts: Will Democrats go along?

Medicare, Obamacare, and other social programs are at the heart of a disconnect over the 'fiscal cliff' in Washington. Republicans appear willing for tax increases but only if Democrats accept big cuts in Medicare and other social programs. ?

By Andrew Taylor,?Associated Press / November 28, 2012

Senate Majority Leader Harry Reid (D) of Nevada pauses as he meets with reporters on Capitol Hill in Washington, Tuesday, Nov. 27, 2012, following a Democratic strategy session. Republicans appear ready to agree to tax increases, but only if Democrats accept big cuts in Medicare and other social programs.

J. Scott Applewhite/AP

Enlarge

Republicans' newfound willingness to consider tax increases to avert the "fiscal cliff" comes with a significant caveat: larger cuts than Democrats seem willing to consider to benefit programs like Medicare, Medicaid and the president's health care overhaul.

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The disconnect on benefit programs, coupled with an impasse between Republicans and the White House over raising tax rates on upper-bracket earners, paints a bleak picture as the clock ticks toward a year-end fiscal debacle of automatic tax increases and harsh cuts to the Pentagon and domestic programs.

Democrats emboldened by the election are moving in the opposite direction from the GOP on curbing spending, refusing to look at cuts that were on the bargaining table just last year. Those include any changes to Social Security, even though President Barack Obama was willing back then to consider cuts in future benefits through lower cost-of-living increases. Obama also considered raising the eligibility age for Medicare, an idea that most Democrats oppose.

"I haven't seen any suggestions on what they're going to do on spending," a frustrated Sen. Orrin Hatch, R-Utah, said Tuesday. "There's a certain cockiness that I've seen that is really astounding to me since we're basically in the same position we were before."

Well, says Obama's most powerful ally on Capitol Hill, the Democrats are willing to tackle spending on entitlement programs if Republicans agree to raise income tax rates on the wealthiest Americans ? a nonstarter with Republicans still in control of the House.

"We hope that they can agree to the tax revenue that we're talking about, and that is rate increases, and as the president's said on a number of occasions, we'll be happy to deal with entitlements," Senate Majority Leader Harry Reid, D-Nev., said Tuesday.

But Reid speaks only in the most general terms, wary of publicly embracing specific ideas like boosting Medicare premiums or raising the program's eligibility age.

At the White House, Obama met with a group of small business owners. Participants described the hour-long meeting as a listening session for Obama, with the business owners urging him to reach an agreement.

"They had one message for the president, which is they need certainty. Please get this deal done as soon as possible. They very much want consumers out there knowing that they're going to have money in their pockets to spend. That's why it's so important to pass the extension of the tax cuts for 98 percent of consumers, 97 percent of all small businesses," said Small Business Administration head Karen Mills.

Obama planned to meet Wednesday with more than a dozen leaders from large corporations, including Lloyd Blankfein of Goldman Sachs, Marissa Mayer of Yahoo!, Brian Roberts of Comcast and Arne Sorenson of Marriott.

Obama hits the road on Friday, visiting a Pennsylvania toy factory and broadcasting his case to extend current tax rates for all but those families making more than $250,000 a year.

Private White House negotiations with top aides to House Speaker John Boehner, R-Ohio, and others are cloaked in secrecy, with no evidence of headway.

"There's been little progress with the Republicans, which is a disappointment to me," Reid, a key negotiator, told reporters on Tuesday. "They talked some happy talk about doing revenues, but we only have a couple weeks to get something done. So we have to get away from the happy talk and start talking about specific things."

Republicans say it's Obama and his Democratic allies on Capitol Hill who are holding back, and they point to a balance of power in official Washington that is little changed by the president's re-election. Republicans still control the House, despite losing seats in the election. Democrats control the Senate.

"Democrats in Congress have downplayed the danger of going over the cliff and continue to rule out sensible spending cuts that must be part of any significant agreement to reduce the deficit," said Michael Steel, spokesman for House Speaker John Boehner, R-Ohio.

Just last year, Obama and top Democrats were willing during budget negotiations with Republicans to take politically risky steps such as reducing the annual inflation adjustment to Social Security retirement payments and raising the eligibility age for Medicare, which provides health care coverage to the elderly.

Now, with new leverage from Obama's election victory and a playing field for negotiations that is more favorable to Democrats than during the talks of the summer of 2011, Democrats are taking a harder line, ruling out any moves on Social Security and all but dismissing ideas like raising the eligibility age for Medicare from 65.

"The election spoke very strongly about the fact that the American people don't want to cut these programs that actually really sustain the middle class in America and allow people to become part of the middle class," said Sen. Tom Harkin, D-Iowa.

"I think they feel somewhat emboldened by the election," said GOP Rep. Tom Price of Georgia. "How could you not when your president is re-elected after running four straight years of trillion dollar-plus deficits?"

Indeed, Obama could be in position to blame Republicans if an impasse results in the government going over the fiscal cliff. Democrats already are portraying GOP lawmakers as hostage-takers willing to let tax rates rise on everyone if lower Bush-era tax rates are not extended for the top 2 percent to 3 percent of earners ? those with incomes above $200,000 for individuals and $250,000 for joint filers.

"One thing Republicans have to realize ? we're in much better shape in January," said Harkin, referring to a time when taxes would have already risen and Democrats would be offering to cut taxes for all but the wealthiest Americans. "Fiscal cliff? I don't care."

Obama's opening position in the negotiations calls for $1.6 trillion in higher taxes over the coming decade, balanced by just $340 billion in cuts to rapidly growing health care programs, generally taken from health care providers instead of beneficiaries. That balance would have to change for Republicans to sign onto any agreement.

Given the crunch of time and the complexity of issues such as tax reform and wringing savings from programs like Medicare, negotiators are working on a two-track process: an initial "down payment" of deficit cuts next month, coupled with work next year on overhauling the tax code and curbing entitlement programs.

Sen. Dick Durbin, D-Ill., a leading Senate liberal and a member of Obama's special 2010 deficit panel ? which drafted a bold deficit reduction plan blending painful entitlement cuts with $2 trillion in higher tax revenues ? weighed in with a demand that any short-term down payment avoid politically sensitive safety net programs.

"Progressives should be willing to talk about ways to ensure the long-term viability of Social Security, Medicare and Medicaid, but those conversations should not be part of a plan to avert the fiscal cliff," Durbin said in a speech at the liberal Center for American Progress think tank in Washington.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/wdNnZOhSBLs/Medicare-social-program-cuts-Will-Democrats-go-along

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Union asks for trustee to supervise Hostess liquidation

Date: Wednesday, November 28, 2012, 8:01am CST - Last Modified: Wednesday, November 28, 2012, 8:15am CST

Source: http://www.bizjournals.com/kansascity/blog/morning_call/2012/11/union-asks-for-trustee-to-supervise.html?ana=RSS&s=article_search

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Military Strategy Forum: General Mike Hostage, Commander, Air Combat Command

The Center for Strategic and International Studies
Invites you to a Military Strategy Forum on?

Maintaining Dominant Combat Airpower in Fiscal Austerity

a discussion with

General Mike Hostage
Commander, Air Combat Command
and
David J. Berteau

CSIS Senior Vice President and Director of the International Security Program

Followed by Q&A with General Hostage, moderated by Kim Wincup, CSIS Senior Adviser, and Nathan Freier, Senior Fellow, International Security Program

Friday November 30, 2012
Breakfast: 8:45 a.m.
Discussion: 9:00-9:30 a.m.
Q&A: 9:30-10:15 a.m.

B1 Conference Room
Center for Strategic and International Studies
1800 K Street, NW
Washington DC, 20006

The Military Strategy Forum Series is Underwritten by Rolls-Royce North America
Please Click Here to RSVP

Dress is business attire or working uniform
?

Source: http://csis.org/event/maintaining-dominant-combat-airpower-fiscal-austerity

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Wednesday, November 28, 2012

COUP-TFII sparks prostate cancer progression

COUP-TFII sparks prostate cancer progression [ Back to EurekAlert! ] Public release date: 28-Nov-2012
[ | E-mail | Share Share ]

Contact: Dipali Pathak
pathak@bcm.edu
713-713-4710
Baylor College of Medicine

HOUSTON (Nov. 29, 2012) Prostate cancer presents a dilemma for patients and the physicians who treat them. Which cancers are essentially indolent and present no risk and which are life threatening? Which can be watched and which need aggressive treatment?

Drs. Ming-Jer and Sophia Tsai, both professors in the department of molecular and cellular biology at Baylor College of Medicine, think a receptor called COUP-TFII that they have long studied may point the way to an answer. In a study that appears online in the journal Nature, they show that high levels (overexpression) of COUP-TFII can overcome a natural barrier to progression of prostate cancer, allowing tumor cells to grow and spread throughout the body a process called metastasis.

"Levels of COUP-TFII provide a good prognostic marker for prostate cancer when added to other known markers of the disease," said Dr. Ming-Jer Tsai.

"COUP-TFII is an important 'second hit' for the progression of prostate cancer and metastasis," said Dr. Sophia Tsai. In other words, one "hit" or mutation might start the process of cells becoming cancerous. The second "hit" would make them more aggressive.

In studies of patient samples, loss of a protein called PTEN or mutations in another signaling pathway called PI3K show up in prostate tumors. However, tumors in which PTEN is lost can remain indolent. One theory is that loss of PTEN increases TGF-beta signaling, which creates a barrier to prostate cancer progression.

The Tsais' studies in mice that lack PTEN show that loss of COUP-TFII inhibits the development of prostate tumors in the animals. When mice have a gene that produces insufficient levels of PTEN, COUP-TFII overexpression enhances prostate tumor progression. Further studies in mice that lost PTEN showed that high levels of COUP-TFII promoted the metastatic spread of the prostate cancer.

Studies in cell cultures and in human tissues confirmed the activity of COUP-TFII in promoting a more aggressive form of prostate cancer that could spread and metastasize.

The next step is find out how to inhibit COUP-TFII and prevent so-called indolent prostate cancers from becoming more aggressive, said Ming-Jer Tsai.

###

Others who took part in this work include Jun Qin, San-Pin Wu, Fangyan Dai, Xin Xie, Chiang-Min Cheng, Chad J. Creighton, Anna Frolov, Gustavo Ayala, Xia Lin, Xin-Hua Feng and, Michael M. Ittmann, all of BCM and Shaw-Jenq Tsai of National Cheng Kung University College of Medicine in Tainan, Taiwan. Ayala is now with the University of Texas Medical School at Houston.

Funding for this study came from the National Institutes of Health (NIH DK62434, DK59820, DK45641 and HL76448).

Dr. Sophia Tsai holds the Gordon Cain Professorship and Dr. Ming-Jer Tsai holds the Charles C. Bell, Jr. and Distinguished Service Professorship in Cell Biology.

For more information on research at Baylor College of Medicine, please go to www.bcm.edu/fromthelab.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


COUP-TFII sparks prostate cancer progression [ Back to EurekAlert! ] Public release date: 28-Nov-2012
[ | E-mail | Share Share ]

Contact: Dipali Pathak
pathak@bcm.edu
713-713-4710
Baylor College of Medicine

HOUSTON (Nov. 29, 2012) Prostate cancer presents a dilemma for patients and the physicians who treat them. Which cancers are essentially indolent and present no risk and which are life threatening? Which can be watched and which need aggressive treatment?

Drs. Ming-Jer and Sophia Tsai, both professors in the department of molecular and cellular biology at Baylor College of Medicine, think a receptor called COUP-TFII that they have long studied may point the way to an answer. In a study that appears online in the journal Nature, they show that high levels (overexpression) of COUP-TFII can overcome a natural barrier to progression of prostate cancer, allowing tumor cells to grow and spread throughout the body a process called metastasis.

"Levels of COUP-TFII provide a good prognostic marker for prostate cancer when added to other known markers of the disease," said Dr. Ming-Jer Tsai.

"COUP-TFII is an important 'second hit' for the progression of prostate cancer and metastasis," said Dr. Sophia Tsai. In other words, one "hit" or mutation might start the process of cells becoming cancerous. The second "hit" would make them more aggressive.

In studies of patient samples, loss of a protein called PTEN or mutations in another signaling pathway called PI3K show up in prostate tumors. However, tumors in which PTEN is lost can remain indolent. One theory is that loss of PTEN increases TGF-beta signaling, which creates a barrier to prostate cancer progression.

The Tsais' studies in mice that lack PTEN show that loss of COUP-TFII inhibits the development of prostate tumors in the animals. When mice have a gene that produces insufficient levels of PTEN, COUP-TFII overexpression enhances prostate tumor progression. Further studies in mice that lost PTEN showed that high levels of COUP-TFII promoted the metastatic spread of the prostate cancer.

Studies in cell cultures and in human tissues confirmed the activity of COUP-TFII in promoting a more aggressive form of prostate cancer that could spread and metastasize.

The next step is find out how to inhibit COUP-TFII and prevent so-called indolent prostate cancers from becoming more aggressive, said Ming-Jer Tsai.

###

Others who took part in this work include Jun Qin, San-Pin Wu, Fangyan Dai, Xin Xie, Chiang-Min Cheng, Chad J. Creighton, Anna Frolov, Gustavo Ayala, Xia Lin, Xin-Hua Feng and, Michael M. Ittmann, all of BCM and Shaw-Jenq Tsai of National Cheng Kung University College of Medicine in Tainan, Taiwan. Ayala is now with the University of Texas Medical School at Houston.

Funding for this study came from the National Institutes of Health (NIH DK62434, DK59820, DK45641 and HL76448).

Dr. Sophia Tsai holds the Gordon Cain Professorship and Dr. Ming-Jer Tsai holds the Charles C. Bell, Jr. and Distinguished Service Professorship in Cell Biology.

For more information on research at Baylor College of Medicine, please go to www.bcm.edu/fromthelab.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/bcom-csp112612.php

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Judge orders tobacco firms to say they lied

?

By Frederic J. Frommer, Associated Press

WASHINGTON --?A federal judge on Tuesday ordered tobacco companies to publish corrective statements that say they lied about the dangers of smoking and that disclose smoking's health effects, including the death on average of 1,200 people a day.?

U.S. District Judge Gladys Kessler previously had said she wanted the industry to pay for corrective statements in various types of advertisements. But Tuesday's ruling is the first time she's laid out what the statements will say.

Each corrective ad is to be prefaced by a statement that a federal court has concluded that the defendant tobacco companies "deliberately deceived the American public about the health effects of smoking."

Among the required statements are that smoking kills more people than murder, AIDS, suicide, drugs, car crashes and alcohol combined, and that "secondhand smoke kills over 3,000 Americans a year."

The corrective statements are part of a case the government brought in 1999 under the Racketeer Influenced and Corrupt Organizations. Kessler ruled in that case in 2006 that the nation's largest cigarette makers concealed the dangers of smoking for decades, and said she wanted the industry to pay for "corrective statements" in various types of ads, both broadcast and print. The Justice Department proposed corrective statements, which Kessler used as the basis for some of the ones she ordered Tuesday.

Tobacco companies had urged Kessler to reject the government's proposed industry-financed corrective statements; the companies called them "forced public confessions." They also said the statements were designed to "shame and humiliate" them. They had argued for statements that include the health effects and addictive qualities of smoking.

Kessler wrote that all of the corrective statements are based on specific findings of fact made by the court.

"This court made a number of explicit findings that the tobacco companies perpetuated fraud and deceived the public regarding the addictiveness of cigarettes and nicotine," she said.

A spokesman for Altria Group Inc., owner of the nation's biggest tobacco company, Philip Morris USA, said the company was studying the court's decision and did not provide any further comment. A spokesman for Reynolds American Inc., parent company of No. 2 cigarette maker, R.J. Reynolds Tobacco Co., said the company was reviewing the ruling and considering its next steps.

The statements Kessler chose included five categories: adverse health effects of smoking; addictiveness of smoking and nicotine; lack of significant health benefit from smoking cigarettes marked as "low tar," "light," etc.; manipulation of cigarette design and composition to ensure optimum nicotine delivery; and adverse health effects of exposure to secondhand smoke.

Among the statements within those categories:

  • "Smoking kills, on average, 1,200 Americans. Every day."?
  • "Defendant tobacco companies intentionally designed cigarettes to make them more addictive."?
  • "When you smoke, the nicotine actually changes the brain ? that's why quitting is so hard."?
  • "All cigarettes cause cancer, lung disease, heart attacks and premature death ? lights, low tar, ultra lights and naturals. There is no safe cigarette."?
  • "Secondhand smoke causes lung cancer and coronary heart disease in adults who do not smoke."?"Children exposed to secondhand smoke are at an increased risk for sudden infant death syndrome (SIDS), acute respiratory infections, ear problems, severe asthma and reduced lung function."?
  • "There is no safe level of exposure to secondhand smoke."?

Justice Department spokesman Charles Miller said the department was pleased with the order.

Matt Myers, president of the Campaign for Tobacco-Free Kids, called it an important ruling.

"The most critical part of the ruling is that it requires the tobacco companies to state clearly that the court found that they deceived the American public and that they are telling the truth now only because the court is ordering them to do so," Myers said in an interview. "This isn't the last word, but this is a vitally important step because this should resolve exactly what the tobacco companies are required to say."

In July, a federal appeals court rejected efforts by the tobacco companies to overrule Kessler's ruling requiring corrective statements. The companies had argued that a 2009 law that gave the Food and Drug Administration authority over the industry eliminated "any reasonable likelihood" that they would commit future RICO violations.

In her ruling Tuesday, Kessler ordered the tobacco companies and Justice Department to meet beginning next month to address how to implement the corrective statements, including whether they will be put in inserts with cigarette packs and on websites, TV and newspaper ads. Those discussions are to conclude by March.

Related stories:


?

Source: http://vitals.nbcnews.com/_news/2012/11/27/15490985-judge-orders-tobacco-firms-to-say-they-lied-about-smoking-dangers?lite

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