FAA grants experimental permit to Virgin Galactic

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Colorectal Cancer: Metastatic: Past Decade ? Colon And Rectal ...

May 31st | Colon And Rectal Surgery

Michael D?Angelica, Kamran Idrees, Philip B. Paty, and Leslie H. Blumgart Approximately 20% of patients with colorectal cancer present with established distant metastases.1 In most cases, the metastases are detectable with noninvasive imaging, and patients can be assigned to AJCC Stage IV before any surgical intervention. Among these patients there is enormous heterogeneity with respect to sites of disease, extent of disease, symptoms, performance status, and comorbidities. The clinical spectrum at the time of diagnosis ranges from the asymptomatic patient with a single metastatic lesion to the rapidly deteriorating patient with colon obstruction and advanced, multiorgan metastases. It is therefore difficult to define rigid treatment algorithms that can be widely applied to all clinical settings. Despite considerable progress in the treatment of advanced colorectal cancer, the vast majority of Stage IV patients are not curable by current treatment protocols. A recent analysis of data from the SEER population-based database estimates that the 5-year survival rate for Stage IV patients diagnosed between 1991 and 2000 was 8%.2 However, despite a low overall cure rate, aggressive treatment is indicated for most patients to extend survival and enhance quality of life. Systemic chemotherapy, endoscopic treatments to palliate obstruction, surgical diversion, and surgical resection all have important roles in treatment of Stage IV patients. Treatment approaches must be individualized based on the extent and resectability of local and distant disease, the presence or absence of bowel obstruction, performance status, and comorbidities. For patients with good performance status and minimal symptoms from their primary cancers, standard treatment is systemic chemotherapy, which is well documented to increase survival and quality of life.3,4 Surgical resection of the primary tumor and, when feasible, of the metastatic lesions can provide excellent palliation and can, in some cases, provide lasting cure.

Related posts:

1. Colorectal Cancer: Liver Metastasis ? Colon And Rectal Surgery
2. Colorectal Cancer ? Colon And Rectal Surgery
3. Distant Metastatic Disease ? Colon And Rectal Surgery
4. Colon Cancer: Stage Iii Disease ? Colon And Rectal Surgery
5. Puberty: Colorectal Cancer ? Colon And Rectal Surgery

Tags: cancer, Colorectal, Decade, Metastatic, past

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Walker says feds approve higher Wis. job numbers

MADISON, Wis. (AP) ? Republican Gov. Scott Walker's administration said Wednesday that the U.S. Bureau of Labor Statistics has finalized higher job numbers for Wisconsin for 2011, which would blunt one of his opponents' biggest arguments against him just six days before he stands for recall.

However, Walker's Democratic opponent in the recall, Milwaukee Mayor Tom Barrett, told reporters that he doesn't believe Walker's administration and he wants to see official confirmation.

"Anybody has a right to be suspicious," Barrett said.

Walker's Department of Workforce Development provided an email to The Associated Press on Wednesday from the bureau's staff that shows it gave final approval to the numbers. The email did not say what number the bureau approved, but Workforce Development spokesman John Dipko said it was 23,608, which would be dramatically better job creation in the state than figures based on a different survey of businesses.

Dipko said the numbers would be provided to the AP on Thursday and published on the state's website Friday.

Though Tuesday's recall was sparked by Walker's proposal effectively ending collective bargaining rights for most state workers, much of the truncated campaign has focused on Walker's performance related to the economy. In an unusual move, Walker released the fresh job creation numbers two weeks ago, before the federal bureau had approved them.

Barrett has accused Walker of "cooking the books" and trying to spin the numbers to his advantage.

The labor bureau isn't scheduled to publish the new numbers until three weeks after the election. No one at the agency's regional office in Chicago answered the phone after hours Wednesday.

However, according to Walker's administration, the final figures confirmed by the bureau show the state gained 23,608 jobs in 2011, rather than losing 33,900 jobs, which was the worst in the nation. That figure would also be 287 higher than the estimate Walker released early.

"You have my personal assurance that is not a made-up number," said Georgia Maxwell, the department's executive assistant.

Walker was jubilant when told of the news after a campaign stop in Janesville.

"More than good news for me, it's good news for the state," a smiling Walker said.

Walker also said Barrett owed people an apology.

Todd Schober, a financial planner and Walker supporter from Racine, said he's always skeptical about what competing campaigns claim but that the positive numbers resonated more with him based on what he's seeing anecdotally.

"I just think we're heading in the right direction," he said.

Even with the improved numbers for 2011, Walker is far from meeting his campaign promise to create 250,000 jobs. He's on pace to create just over 94,000.

A Marquette University Law School released Wednesday poll showed Walker with a narrow 7-point lead over Barrett, 52 percent to 45 percent. The poll's margin of error was 4.1 percentage points. In the same poll two weeks ago Walker held a 6-point lead, 50 percent to 44 percent.

The latest random telephone poll of 600 likely voters was done between May 23 and Thursday.

The poll also showed that more respondents ? 50 percent to 43 percent ? believed Walker would do a better job with the economy than Barrett. That is similar to two weeks ago, when Walker held a 48-41 edge on that question. That question polled 720 registered voters and had a smaller 3.7 percentage point margin of error.

Meanwhile, out-of-state donors kept pumping cash into Walker's campaign last month.

Reports filed with state elections officials Tuesday show Walker, aided by a quirk in state law that eliminates contribution limits for recall targets, collected $5.9 million between April 24 and Wednesday. Almost two-thirds of that money ? $3.7 million ? came from contributors who listed an address outside Wisconsin.

Barrett, meanwhile, raised $3.4 million between April 24 and Wednesday, with 70 percent of his money coming from donors with Wisconsin addresses, the reports showed.

Barrett has raised a total of $4.2 million since he jumped into the recall race in late March, while Walker has raised $31 million since winning office.

___

Associated Press writers Carrie Antlfinger in Milwaukee, Dinesh Ramde in Racine, Wis., and Todd Richmond in Madison, Wis., contributed to this report.

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Critical Home Improvement Projects For Safety Purposes

This article has been viewed 6 times.

Most people think that repairs and upgrades are the only things involved in home improvement. However, you will discover that there are a lot of home improvement projects that are based on taking safety precautions. Obviously it is a wise move to inspect your home for possible safety hazards. If you aren?t too sure of what you should be looking for, then consider asking your local fire department to send someone along to have a look. You will find that most fire departments are more than willing to provide you with assistance. The fire inspector will also probably be able to test your electrical system for problems as well. If you have a family, then this is essential for you to do as soon as possible.

Chances are that there are home improvement projects waiting to be done in your home. While some projects are quite complex to solve there are others that have simpler solutions. If you are not experienced or knowledgeable, you can read up on it or hire a house inspector to take a look. For a damp basement all you really need is a proper sealant most of the time. Or you could simply install a dehumidifier. But before you do anything, make sure you know where the water is coming in.

You need to make your home as safe as possible, if you haven?t done so yet. This means anything to do with fire and electrical safety as well as home security. You will have to decide on your priorities and think about which project you should handle first. You will feel much better having a sprinkler system, so install one as soon as possible if your home can handle it. You might be surprised to find out that they aren?t quite as expensive as you think. You can always get a professional company to install it for you or a certified freelance contractor.

In terms of indoor climate control, this is an area where people are trying to innovate regularly and to integrate new designs and technology. The ultimate objective is to have a highly energy efficient system to heat and cool a building. Undoubtedly, the newer systems will require something of an investment. You will have to analyze things from a strategic perspective. Your investment will eventually be repaid by the savings you make on your bills and you will then end up in the black. These systems come with things such as selective climate controls. You can program these systems to work in only particular areas of your property at certain times, leading to nice savings on the bills. How fun home improvement projects happen to be depends largely on your attitude about doing them. Sometimes though you?re just going to have to trudge through. If you are always on the lookout for ways to make this a positive learning experience it will be much better.

For more points about debt management plan there is plenty of details not outlined in this post, find those details at Author's blog to uncover further details.

HTML Ready Article You Can Place On Your Site. (do not remove any attribution to source or author) <title>GMT Articles | Critical Home Improvement Projects For Safety Purposes</title><h3>Critical Home Improvement Projects For Safety Purposes</h3><p>By: </p><p>Most people think that repairs and upgrades are the only things involved in home improvement. However, you will discover that there are a lot of home improvement projects that are based on taking safety precautions. Obviously it is a wise move to inspect your home for possible safety hazards. If you aren't too sure of what you should be looking for, then consider asking your local fire department to send someone along to have a look. You will find that most fire departments are more than willing to provide you with assistance. The fire inspector will also probably be able to test your electrical system for problems as well. If you have a family, then this is essential for you to do as soon as possible. </p><p>Chances are that there are home improvement projects waiting to be done in your home. While some projects are quite complex to solve there are others that have simpler solutions. If you are not experienced or knowledgeable, you can read up on it or hire a house inspector to take a look. For a damp basement all you really need is a proper sealant most of the time. Or you could simply install a dehumidifier. But before you do anything, make sure you know where the water is coming in. </p><p>You need to make your home as safe as possible, if you haven't done so yet. This means anything to do with fire and electrical safety as well as home security. You will have to decide on your priorities and think about which project you should handle first. You will feel much better having a sprinkler system, so install one as soon as possible if your home can handle it. You might be surprised to find out that they aren't quite as expensive as you think. You can always get a professional company to install it for you or a certified freelance contractor. </p><p>In terms of indoor climate control, this is an area where people are trying to innovate regularly and to integrate new designs and technology. The ultimate objective is to have a highly energy efficient system to heat and cool a building. Undoubtedly, the newer systems will require something of an investment. You will have to analyze things from a strategic perspective. Your investment will eventually be repaid by the savings you make on your bills and you will then end up in the black. These systems come with things such as selective climate controls. You can program these systems to work in only particular areas of your property at certain times, leading to nice savings on the bills. How fun home improvement projects happen to be depends largely on your attitude about doing them. Sometimes though you're just going to have to trudge through. If you are always on the lookout for ways to make this a positive learning experience it will be much better.</p><p>For more points about debt management plan there is plenty of details not outlined in this post, find those details at Author's blog to uncover further details.</p><p><b>Article Courtesy of</b> GMT Articles<br /></p>

This article was prepared for you by DuqueWelsh913, one of our 'Authors'.
Visit this authors profile page and learn more about them & the articles they write.

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GAYTWOGETHER: Gay Relationships: "If I'm So Darned Cute, Why ...

One of the most common concerns that come through my service from gay singles is the difficulty they speak of securing dates with quality and compatible men; and sometimes it?s even just landing a date of any kind! Invitations for sex seem more readily accessible and the frustration and disappointment is the predominant emotion experienced by these relationship-minded singles who have good heads on their shoulders and are ready and available for love, but just can?t seem to find others who mirror their desire for substance and depth in their involvements.

After a series of let-downs, it can really start messing with your sense of optimism and positive outlook. You might begin to feel jaded and develop resentments toward the whole institution of dating and the gay community, questioning whether gay relationships really can work. Worse yet, you might begin turning these attacking feelings against yourself in the form of developing beliefs that there?s something wrong or defective with you in the face of so much perceived rejection.

Ouch! Stop the madness! You cannot allow all the hard work it took for you to develop and grow yourself into the solid man that you?ve become to be tampered with by the inherent challenges of dating.

It?s Not You, It?s Me

So why is it so hard for gay men to meet and participate in the courtship process? What follows here is a list of reasons (and there?s probably more!) that might be contributory factors to the obstacles we encounter in our efforts to find quality partners.

This list isn?t intended to further reinforce hopelessness or to make you give up on your quest and go running for the hills, but instead is offered to showcase the reality that gay dating CAN be difficult (but not insurmountable!). So before you start beating up on yourself for your absent dating life, recognize that the system of gay dating itself as it now stands holds many dysfunctional politics that make this situation more difficult for us.

* Gays supposedly make up only 10% of the total population, thereby decreasing our dating pool.

* We don?t wear the word ?GAY? stamped on our foreheads; therefore, it makes things much more difficult compared to our heterosexual counterparts to determine who ?plays ball on our field? when you?re out in public and can inhibit us from approaching men we find interesting.

* Due to our homophobic society, gays grow up with the threat of discrimination, ridicule, harassment, and abuse and violence. This wreaks havoc on our self-esteem, confidence, and identity. As such, our dating pool tends to possess proportionately more men struggling with mental health issues, substance abuse and other addictions, and those unable or unwilling to ?come out? and achieve a sense of gay pride that would have them be more visible in the community.

* There is an absence of positive role models to emulate what healthy gay relationships look like or how they function. Unlike our heterosexual counterparts, there are no ascribed developmental tasks or rites-of-passage in adolescence to teach us how to date or honor our same-sex involvements. As such, many men feel directionless in dating and can sabotage potential relationships. Combined with internalized homophobia, fears of intimacy, and conflicts around masculinity, sexual orientation, and identity?it?s no wonder it?s so hard!

* The gay community tends to sexualize gay men, their bodies, and their relationships. Coupled with glamorizing youth, objectification is rampant and sex seems to take center stage. Until the community as a whole makes some radical changes in our views toward and portrayals of sexuality and gay eroticism, healthy dating and relationship development and maintenance will likely be challenged and overshadowed.

Action Challenges

So while these systemic challenges due pose potential barriers to your dating life, they only have to have power if you allow them to do so. We are not victims; growing up gay requires significant courage, perseverance, and resilience. To survive and prosper through this means we can handle anything.

Step one requires taking back personal control and refusing to allow these dating challenges and disappointments to have emotional power over you.

(Continued Tomorrow)

? Dr. Brian Rzepczynski, The Gay Love Coach

The suggestions and feedback offered in this column are but one perspective of multiple approaches to dealing with problems or challenges. Information provided in articles and advice columns should not be used as a substitute for coaching or therapy when these services are needed. None of this information should be your only source when making important life decisions. This information should not be used for diagnosing or treating a particular problem, nor should it take the place of a consultation with a trained professional. It is your responsibility to consult a professional prior to making any life decisions.

Dr. Brian Rzepczynski, contributing author to GAYTWOGETHER, is one of the leading love coaches for the gay community. As a licensed dating and relationship coach, Dr. Brian Rzepczynski, DHS, MSW has over 18 years experience as a psychotherapist and life coach specializing in helping GLBT individuals and couples develop and maintain successful and fulfilling intimate relationships. He holds a doctorate degree in human sexuality from the Institute for Advanced Study of Human Sexuality and a master?s degree in clinical social work from Western Michigan University. He also runs a successful private therapy practice, Personal Victory Counseling, Inc. http://thegaylovecoach.com

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Dozens detained at Russian opposition rallies

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